Educational content only. Not medical advice, and no doctor-patient relationship is created. Read the medical disclaimer
Peptide · nasal
Semax
Also known as: ACTH (4–10) analog
A nasal peptide developed in Russia for stroke recovery and cognition.
Tier 2 · Prepare & watch
Grade C · Limited human evidence
Educational content only, not medical advice. Discussion here does not mean this therapy is prescribed by Youthful Medicine or available to you. Read the medical disclaimer
U.S. regulatory status
Not FDA-approved. Recommended (8–5) for the 503A list by FDA’s advisory committee in July 2026; FDA has not finalized that decision. Not currently offered.
What it is
A synthetic analog of a fragment of ACTH, with a short tail added for stability.
How it is thought to work
Studies suggest it raises brain-derived neurotrophic factor (BDNF) and affects dopamine and serotonin signaling.
Animations simplify biology for teaching. They are not a claim that this peptide works this way in people.
What the research shows
Most clinical studies are Russian, small and not independently replicated.
Safety and considerations
Short-term use appears well tolerated in published reports; independent safety data are limited.
Our position
Prepare and watch.
Video lesson
AT A GLANCE
Quadrant
Regenerative & Cellular Health
Sub-pillar
Neural & Recovery
Tier
Tier 2 · Prepare & watch
Evidence grade
Grade C · Limited human evidence
Last reviewed
Is this right for you?
Only a physician who has evaluated you can answer that. Consultations are with licensed Youthful Medicine providers.
Never use products labeled “research use only” or “not for human use.” Purity, dose and sterility are unverified.