Educational content only. Not medical advice, and no doctor-patient relationship is created. Read the medical disclaimer
Peptide · mitochondria-derived
MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA type-c
A small peptide encoded by mitochondrial DNA that acts like an exercise signal in animal studies.
Tier 2 · Prepare & watch
Grade D · Preclinical only
Educational content only, not medical advice. Discussion here does not mean this therapy is prescribed by Youthful Medicine or available to you. Read the medical disclaimer
U.S. regulatory status
Not FDA-approved. Recommended (7–5) for the 503A list by FDA’s advisory committee in July 2026 for obesity and osteoporosis; FDA has not finalized that decision. Not currently offered.
What it is
A 16-amino-acid peptide made from instructions in the mitochondria’s own genome, first described in 2015.
How it is thought to work
In animals it activates AMPK, a cellular energy sensor, improving insulin sensitivity and how muscle uses glucose and fat.
Animations simplify biology for teaching. They are not a claim that this peptide works this way in people.
What the research shows
Strong animal data. Human evidence is early and limited, and we say so plainly.
Safety and considerations
Human safety data are minimal. Sourcing quality is a serious concern outside licensed pharmacies.
Our position
Prepare and watch. A compelling story, not yet a human-proven therapy.
Video lesson
AT A GLANCE
Quadrant
Metabolic & Obesity Health
Sub-pillar
Also Cellular Energy
Tier
Tier 2 · Prepare & watch
Evidence grade
Grade D · Preclinical only
Last reviewed
Is this right for you?
Only a physician who has evaluated you can answer that. Consultations are with licensed Youthful Medicine providers.
Never use products labeled “research use only” or “not for human use.” Purity, dose and sterility are unverified.